(BY-oh-MAR-ker) A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. BDNF is one of MUJN’s key biomarkers and part of our Neuro-4 brain health panel.

Brain-derived neurotrophic factor (BDNF):
Neurotrophins are chemicals that help regulate neuron formation (neurogenesis). Scientists believe BDNF is amongst the most active neurotrophins, also referred to as “Miracle-Grow for the brain” by Harvard neuropsychiatrist John J. Ratey (MD). BDNF plays an important role in neuroplasticity, the brain’s ability to promote the survival of nerve cells (neurons) and connections between nerve cells (synapses). The synapses can change and adapt over time in response to experience and environment, called synaptic plasticity. The BDNF gene regulates synaptic plasticity, which is important for learning and memory.

Blood BDNF decreases with advanced age. These levels are significantly low in people with major depression compared to healthy people. BDNF levels can also be affected by other factors: stress, sleep, exercise, and nutrition.